abstract：BACKGROUND:The balanced synthesis of membrane phospholipids, fatty acids and cell wall constituents is a vital facet of bacterial physiology, but there is little known about the biochemical control points that coordinate these activities in Gram-positive bacteria. In Escherichia coli, the glycerol-phosphate acyltransfe...

journal_title：BMC microbiology

authors： Parsons JB,Yao J,Jackson P,Frank M,Rock CO

更新日期：2013-11-16 00:00:00

abstract：BACKGROUND:Polymicrobial infections are responsible for significant mortality and morbidity in adults and children. Staphylococcus epidermidis and Candida albicans are the most frequent combination of organisms isolated from polymicrobial infections. Vascular indwelling catheters are sites for mixed species biofilm for...

journal_title：BMC microbiology

authors： Pammi M,Liang R,Hicks J,Mistretta TA,Versalovic J

更新日期：2013-11-14 00:00:00

abstract：BACKGROUND:Extracellular aspartic proteinase (MCAP) produced by Mucor circinelloides in solid state fermentations has been shown to possess milk clotting activity and represents a potential replacement for bovine chymosin in cheese manufacturing. Despite its prospects in the dairy industry, the molecular characteristic...

journal_title：BMC microbiology

authors： Gama Salgado JA,Kangwa M,Fernandez-Lahore M

更新日期：2013-11-09 00:00:00

abstract：BACKGROUND:Abundant populations of bacteria have been observed on Mir and the International Space Station. While some experiments have shown that bacteria cultured during spaceflight exhibit a range of potentially troublesome characteristics, including increases in growth, antibiotic resistance and virulence, other stu...

journal_title：BMC microbiology

authors： Kim W,Tengra FK,Shong J,Marchand N,Chan HK,Young Z,Pangule RC,Parra M,Dordick JS,Plawsky JL,Collins CH

更新日期：2013-11-06 00:00:00

abstract：BACKGROUND:Lactic acid bacteria (LAB) has been considered a beneficial bacterial group, found as part of the microbiota of diverse hosts, including humans and various animals. However, the mechanisms of how hosts and LAB interact are still poorly understood. Previous work demonstrates that 13 species of Lactobacillus a...

journal_title：BMC microbiology

authors： Butler È,Alsterfjord M,Olofsson TC,Karlsson C,Malmström J,Vásquez A

更新日期：2013-10-22 00:00:00

abstract：BACKGROUND:Fungi are the second most abundant type of human pathogens. Invasive fungal pathogens are leading causes of life-threatening infections in clinical settings. Toxicity to the host and drug-resistance are two major deleterious issues associated with existing antifungal agents. Increasing a host's tolerance and...

journal_title：BMC microbiology

authors： Kidane YH,Lawrence C,Murali TM

更新日期：2013-10-07 00:00:00

abstract：BACKGROUND:Coxiella burnetii is a Gram-negative intracellular bacterial pathogen that replicates within a phagolysosome-like parasitophorous vacuole (PV) of macrophages. PV formation requires delivery of effector proteins directly into the host cell cytoplasm by a type IVB secretion system. However, additional secretio...

journal_title：BMC microbiology

authors： Stead CM,Omsland A,Beare PA,Sandoz KM,Heinzen RA

更新日期：2013-10-05 00:00:00

abstract：BACKGROUND:Salmonella enterica is a causative agent of foodborne gastroenteritis and the systemic disease known as typhoid fever. This bacterium uses two type three secretion systems (T3SSs) to translocate protein effectors into host cells to manipulate cellular function. Salmonella pathogenicity island (SPI)-2 encodes...

journal_title：BMC microbiology

authors： Cooper CA,Mulder DT,Allison SE,Pilar AV,Coombes BK

更新日期：2013-10-04 00:00:00

abstract：BACKGROUND:The resurgence of multi-drug resistant tuberculosis (MDR-TB) and HIV associated tuberculosis (TB) are of serious global concern. To contain this situation, new anti-tuberculosis drugs and reduced treatment regimens are imperative. Recently, a nitroimidazole, PA-824, has been shown to be active against both r...

journal_title：BMC microbiology

authors： Somasundaram S,Anand RS,Venkatesan P,Paramasivan CN

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori has diverged in parallel to its human host, leading to distinct phylogeographic populations. Recent evidence suggests that in the current human mixing in Latin America, European H. pylori (hpEurope) are increasingly dominant at the expense of Amerindian haplotypes (hspAmerind). This pheno...

journal_title：BMC microbiology

authors： Maldonado-Contreras A,Mane SP,Zhang XS,Pericchi L,Alarcón T,Contreras M,Linz B,Blaser MJ,Domínguez-Bello MG

更新日期：2013-09-19 00:00:00

abstract：BACKGROUND:Staphylococcus aureus is an opportunistic commensal bacterium that mostly colonizes the skin and soft tissues. The pathogenicity of S. aureus is due to both its ability to resist antibiotics, and the production of toxins. Here, we characterize a group of genes responsible for toxin production and antibiotic ...

journal_title：BMC microbiology

authors： Sina H,Ahoyo TA,Moussaoui W,Keller D,Bankolé HS,Barogui Y,Stienstra Y,Kotchoni SO,Prévost G,Baba-Moussa L

更新日期：2013-08-08 00:00:00

abstract：BACKGROUND:The species Pectobacterium carotovorum includes a diverse subspecies of bacteria that cause disease on a wide variety of plants. In Morocco, approximately 95% of the P. carotovorum isolates from potato plants with tuber soft rot are P. carotovorum subsp. carotovorum. However, identification of this pathogen ...

journal_title：BMC microbiology

authors： Kettani-Halabi M,Terta M,Amdan M,El Fahime el M,Bouteau F,Ennaji MM

更新日期：2013-07-29 00:00:00

abstract：BACKGROUND:The lung of patients with cystic fibrosis (CF) is particularly sensitive to Pseudomonas aeruginosa. This bacterium plays an important role in the poor outcome of CF patients. During the disease progress, first acquisition of P. aeruginosa is the key-step in the management of CF patients. Quantitative PCR (qP...

journal_title：BMC microbiology

authors： Le Gall F,Le Berre R,Rosec S,Hardy J,Gouriou S,Boisramé-Gastrin S,Vallet S,Rault G,Payan C,Héry-Arnaud G

更新日期：2013-06-21 00:00:00

abstract：BACKGROUND:Adhesion to surfaces facilitates many crucial functions of microbes in their natural habitats. Thus understanding the mechanism of microbial adhesion is of broad interest to the microbiology research community. RESULTS:We report a study by fluorescence imaging and atomic force microscopy on the growth in si...

journal_title：BMC microbiology

authors： Li G,Brun YV,Tang JX

更新日期：2013-06-19 00:00:00

abstract：BACKGROUND:Moraxella catarrhalis is a human-specific gram-negative bacterium readily isolated from the respiratory tract of healthy individuals. The organism also causes significant health problems, including 15-20% of otitis media cases in children and ~10% of respiratory infections in adults with chronic obstructive ...

journal_title：BMC microbiology

authors： Balder R,Shaffer TL,Lafontaine ER

更新日期：2013-06-19 00:00:00

abstract：BACKGROUND:The global spread of bacterial resistance has given rise to a growing interest in new anti-bacterial agents with a new strategy of action. Pilicides are derivatives of ring-fused 2-pyridones which block the formation of the pili/fimbriae crucial to bacterial pathogenesis. They impair by means of a chaperone-...

journal_title：BMC microbiology

authors： Piatek R,Zalewska-Piatek B,Dzierzbicka K,Makowiec S,Pilipczuk J,Szemiako K,Cyranka-Czaja A,Wojciechowski M

更新日期：2013-06-12 00:00:00

abstract：BACKGROUND:The ATP-Binding Cassette (ABC) functional superfamily includes integral transmembrane exporters that have evolved three times independently, forming three families termed ABC1, ABC2 and ABC3, upon which monophyletic ATPases have been superimposed for energy-coupling purposes [e.g., J Membr Biol 231(1):1-10, ...

journal_title：BMC microbiology

authors： Zheng WH,Västermark Å,Shlykov MA,Reddy V,Sun EI,Saier MH Jr

更新日期：2013-05-06 00:00:00

abstract：BACKGROUND:The bacterial surface protein internalin (InlA) is a major virulence factor of the food-born pathogen Listeria monocytogenes. It plays a critical role in the bacteria crossing the host intestinal barrier by a species-specific interaction with the cell adhesion molecule E-cadherin. In mice, the interaction of...

journal_title：BMC microbiology

authors： Bergmann S,Beard PM,Pasche B,Lienenklaus S,Weiss S,Gahan CG,Schughart K,Lengeling A

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:GeoChip 3.0, a microbial functional gene array, containing ~28,000 oligonucleotide probes and targeting ~57,000 sequences from 292 functional gene families, provided a powerful tool for researching microbial community structure in natural environments. The alpine meadow is a dominant plant community in the Q...

journal_title：BMC microbiology

authors： Zhang Y,Lu Z,Liu S,Yang Y,He Z,Ren Z,Zhou J,Li D

更新日期：2013-03-29 00:00:00

abstract：BACKGROUND:Bovicin HC5 is an antimicrobial peptide that shows a broad spectrum of activity and potential for biotechnological and therapeutic applications. To gain insight about the safety of bovicin HC5 application, the histological and immunostimulatory effects of orally administrated bovicin HC5 to BALB/c mice were ...

journal_title：BMC microbiology

authors： Paiva AD,Fernandes KM,Dias RS,Rocha Ados S,Oliveira LL,Neves CA,Paula SO,Mantovani HC

更新日期：2013-03-27 00:00:00

abstract：BACKGROUND:The plasma membrane plays an essential role in selective permeability, compartmentalization, osmotic balance, and cellular uptake. The characteristics and functions of cyanobacterial membranes have been extensively investigated in recent years. Cell-penetrating peptides (CPPs) are special nanocarriers that c...

journal_title：BMC microbiology

authors： Liu BR,Huang YW,Lee HJ

更新日期：2013-03-14 00:00:00

abstract：BACKGROUND:The aminoglycoside-resistance genes encoding aminoglycoside modifying enzymes and 16S rRNA methyltransferases are main factors contributing to increasing resistance to aminoglycosides. Characterization and distribution of antimicrobial resistance gene profiles provide important information on the potential d...

journal_title：BMC microbiology

authors： Hu X,Xu B,Yang Y,Liu D,Yang M,Wang J,Shen H,Zhou X,Ma X

更新日期：2013-03-14 00:00:00

abstract：BACKGROUND:The life cycle of a bacteriophage has tightly programmed steps to help virus infect its host through the interactions between the bacteriophage and its host proteins. However, bacteriophage-host protein interactions in high temperature environment remain poorly understood. To address this issue, the protein ...

journal_title：BMC microbiology

authors： Chen Y,Wei D,Wang Y,Zhang X

更新日期：2013-02-26 00:00:00

abstract：BACKGROUND:A growing body of evidence suggests that Mycobacterium tuberculosis (Mtb) uses the host's cholesterol as a source of carbon and energy during infection. Strains defective in cholesterol transport or degradation exhibit attenuated growth in activated macrophages and diminished infectivity in animal models. Th...

journal_title：BMC microbiology

authors： Brzezinska M,Szulc I,Brzostek A,Klink M,Kielbik M,Sulowska Z,Pawelczyk J,Dziadek J

更新日期：2013-02-20 00:00:00

abstract：BACKGROUND:Mycoplasmas-contamination of Orientia tsutsugamushi, one of the obligated intracellular bacteria, is a very serious problem in in vitro studies using cell cultures because mycoplasmas have significant influence on the results of scientific studies. Only a recommended decontamination method is to passage the ...

journal_title：BMC microbiology

authors： Ogawa M,Uchiyama T,Satoh M,Ando S

更新日期：2013-02-08 00:00:00

abstract：BACKGROUND:Mycobacterium abscessus group includes antibiotic-resistant, opportunistic mycobacteria that are responsible for sporadic cases and outbreaks of cutaneous, pulmonary and disseminated infections. However, because of their close genetic relationships, accurate discrimination between the various strains of thes...

journal_title：BMC microbiology

authors： Sassi M,Ben Kahla I,Drancourt M

更新日期：2013-01-07 00:00:00

abstract：BACKGROUND:Plant endophytic bacteria play an important role benefiting plant growth or being pathogenic to plants or organisms that consume those plants. Multiple species of bacteria have been found co-inhabiting plants, both cultivated and wild, with viruses and fungi. For these reasons, a general understanding of pla...

journal_title：BMC microbiology

authors： Ding T,Palmer MW,Melcher U

更新日期：2013-01-03 00:00:00

abstract：BACKGROUND:Hepatitis B virus (HBV), because of its error-prone viral polymerase, has a high mutation rate leading to widespread substitutions, deletions, and insertions in the HBV genome. Deletions may significantly change viral biological features complicating the progression of liver diseases. However, the clinical c...

journal_title：BMC microbiology

authors： Zhang D,Dong P,Zhang K,Deng L,Bach C,Chen W,Li F,Protzer U,Ding H,Zeng C

更新日期：2012-12-28 00:00:00

abstract：BACKGROUND:Streptococcus canis is an important opportunistic pathogen of dogs and cats that can also infect a wide range of additional mammals including cows where it can cause mastitis. It is also an emerging human pathogen. RESULTS:Here we provide characterization of the first genome sequence for this species, strai...

journal_title：BMC microbiology

authors： Richards VP,Zadoks RN,Pavinski Bitar PD,Lefébure T,Lang P,Werner B,Tikofsky L,Moroni P,Stanhope MJ

更新日期：2012-12-18 00:00:00

abstract：BACKGROUND:Leptospires lack many of the homologs for oxidative defense present in other bacteria, but do encode homologs of the Bacteriodes aerotolerance (Bat) proteins, which have been proposed to fulfill this function. Bat homologs have been identified in all families of the phylum Spirochaetes, yet a specific functi...

journal_title：BMC microbiology

authors： Stewart PE,Carroll JA,Dorward DW,Stone HH,Sarkar A,Picardeau M,Rosa PA

更新日期：2012-12-13 00:00:00

abstract：BACKGROUND:The evolution of mycoplasmas from a common ancestor with Firmicutes has been characterized not only by genome down-sizing but also by horizontal gene transfer between mycoplasma species sharing a common host. The mechanisms of these gene transfers remain unclear because our knowledge of the mycoplasma mobile...

journal_title：BMC microbiology

authors： Breton M,Tardy F,Dordet-Frisoni E,Sagne E,Mick V,Renaudin J,Sirand-Pugnet P,Citti C,Blanchard A

更新日期：2012-11-12 00:00:00

abstract：BACKGROUND:Bacillus sp. H2O-1, isolated from the connate water of a Brazilian reservoir, produces an antimicrobial substance (denoted as AMS H2O-1) that is active against sulfate reducing bacteria, which are the major bacterial group responsible for biogenic souring and biocorrosion in petroleum reservoirs. Thus, the u...

journal_title：BMC microbiology

authors： Korenblum E,de Araujo LV,Guimarães CR,de Souza LM,Sassaki G,Abreu F,Nitschke M,Lins U,Freire DM,Barreto-Bergter E,Seldin L

更新日期：2012-11-07 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei is the etiological agent of melioidosis and a CDC category B select agent with no available effective vaccine. Previous immunizations in mice have utilized the lipopolysaccharide (LPS) as a potential vaccine target because it is known as one of the most important antigenic epitopes ...

journal_title：BMC microbiology

authors： Stone JK,Mayo M,Grasso SA,Ginther JL,Warrington SD,Allender CJ,Doyle A,Georgia S,Kaestli M,Broomall SM,Karavis MA,Insalaco JM,Hubbard KS,McNew LA,Gibbons HS,Currie BJ,Keim P,Tuanyok A

更新日期：2012-11-05 00:00:00

abstract：BACKGROUND:Enterohemorrhagic Escherichia coli (EHEC) colonizes the intestinal epithelium and causes attaching and effacing (A/E) lesions. Expression of virulence genes, particularly those from the locus of the enterocyte effacement (LEE) pathogenicity island is required for the formation of a type three secretion syste...

journal_title：BMC microbiology

authors： Hansen AM,Jin DJ

更新日期：2012-10-11 00:00:00

abstract：BACKGROUND:Streptococcus gordonii is one of several species that can initiate the formation of oral biofilms that develop into the complex multispecies microbial communities referred to as dental plaque. It is in the context of dental plaque that periodontal pathogens such as Porphyromonas gingivalis cause disease. We ...

journal_title：BMC microbiology

authors： Hendrickson EL,Wang T,Dickinson BC,Whitmore SE,Wright CJ,Lamont RJ,Hackett M

更新日期：2012-09-18 00:00:00

abstract：BACKGROUND:The compatible solute trehalose is involved in the osmostress response of Rhizobium etli, the microsymbiont of Phaseolus vulgaris. In this work, we reconstructed trehalose metabolism in R. etli, and investigated its role in cellular adaptation and survival to heat and desiccation stress under free living con...

journal_title：BMC microbiology

authors： Reina-Bueno M,Argandoña M,Nieto JJ,Hidalgo-García A,Iglesias-Guerra F,Delgado MJ,Vargas C

更新日期：2012-09-17 00:00:00

abstract：BACKGROUND:In the past decade, researchers have proposed that the pldA gene for outer membrane phospholipase A (OMPLA) is important for bacterial colonization of the human gastric ventricle. Several conserved Helicobacter pylori genes have distinct genotypes in different parts of the world, biogeographic patterns that ...

journal_title：BMC microbiology

authors： Vollan HS,Tannaes T,Yamaoka Y,Bukholm G

更新日期：2012-09-13 00:00:00

abstract：BACKGROUND:The type IV secretion system (T4SS) can be classified as a large family of macromolecule transporter systems, divided into three recognized sub-families, according to the well-known functions. The major sub-family is the conjugation system, which allows transfer of genetic material, such as a nucleoprotein, ...

journal_title：BMC microbiology

authors： Souza RC,del Rosario Quispe Saji G,Costa MO,Netto DS,Lima NC,Klein CC,Vasconcelos AT,Nicolás MF

更新日期：2012-08-09 00:00:00

abstract：BACKGROUND:adhC from Haemophilus influenzae encodes a glutathione-dependent alcohol dehydrogenase that has previously been shown to be required for protection against killing by S-nitrosoglutathione (GSNO). This group of enzymes is known in other systems to be able to utilize substrates that form adducts with glutathio...

journal_title：BMC microbiology

authors： Kidd SP,Jiang D,Tikhomirova A,Jennings MP,McEwan AG

更新日期：2012-07-31 00:00:00

abstract：BACKGROUND:Avian pathogenic Escherichia coli (APEC) and uropathogenic E. coli (UPEC) are the two main subsets of extraintestinal pathogenic E. coli (ExPEC). Both types have multiple iron acquisition systems, including heme and siderophores. Although iron transport systems involved in the pathogenesis of APEC or UPEC ha...

journal_title：BMC microbiology

authors： Gao Q,Wang X,Xu H,Xu Y,Ling J,Zhang D,Gao S,Liu X

更新日期：2012-07-20 00:00:00